Recent development of an intravenous cannulation technic and pharmaceutical product has demonstrated that growth, wound healing and weight gain, including a positive nitrogen balance, can be achieved in animals and man by long term total non-enteric, intravenous feedings.
The authors present 8 cases of successful total hyperalimentation, used as the sole means of nutritional support for prolonged periods, and review recent literatureson the total intravenous feedings.
1. The total parenteral hyperalimentation was done on 8 cases for past one year at Seoul National University Hospital.
2. The composition of the hypertonic solution used in this study was essentially same as Dudrick´s formula, using 50% glucose and either 5% protein hydrolysate or commercially available amino acid preparation.
3. Average total daily calorie administered was 2, 500 calories and average amount of nitrogen was 15 gm. Daily requirement of electrolytes, vitamins and other elements were supplemented according to the. laboratory data.
4. Because of less availability of "Intracath" catheter, puncture of 2 subclavian veins and cut downs of 1 axillary vein, 4 cubital veins and 1 greater saphenoous vein were performed.
5. Body weight was increased in 2 cases, maintained in 4 cases, and 2 case were couldn´t weighed.
6. Average blood sugar was 136-148 mg%, and urinary sugar was 2+. Average serum albumin level was 2. 5 gm% before hyperalimentation. Even though the albumin level was not markedly changed, the total serum protein was increased due to a increase of serum globulin level. EUN was 914.6 gm%.
7. There was not any serious complication due to hyperalimentation.
In conclusion, the total parenteral hyperalimentation allows adequate metabolic support and prevention of catabolism of the patient with severe nutrition debility or prolonged disability of the gastrointestinal tract. However, this hyperalimentation require cooperation of the physician, nurse, pharmacist and ether hospital personnel.
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